Many PDK1-dependent AGC kinases (e.g., AKT/PKB, RSK, PKC, S6K, and SGK) are downstream effectors in the PI3K/protein kinase B (AKT) or mitogen-activated protein kinase (MAPK) growth factor signalling pathways and are aberrantly activated in various types of cancer in humans [60]. The gene discussed is RPS6KB1; the disease is cancer.