To this end, 6-month-old male adipose-specific UCP1 KI pigs and age-matched WT controls were injected with streptozotocin for 5 days to induce diabetes, followed by feeding with high-fat, high-cholesterol diet (HFHC) to induce vasculopathology (Fig. 7, A and B). The gene discussed is UCP1; the disease is diabetes mellitus.