Transiently knockdown of MEN1 caused a significant down-regulation of CDKN1A and TP53 transcripts, as well as after treatment with staurosporine, proving a direct correlation between MEN1 and the master regulators of cell fate as previously found in gamma-irradiated rat insulinoma cells where, MEN1 mutated variants lowered the apoptotic response [17]. This evidence concerns the gene MEN1 and pancreatic insulinoma.