The results of the present study indicated that CLB treatment decreased the abundance of Deltaproteobacteria, Desulfovibrionales, Desulfovibrionaceae, and Desulfovibrio, and CLB played an anxiolytic role, which was consistent with the effect of chlorogenic acid, an antidepressant ingredient, in a rat model of major depression disorder (Song et al., 2019). The gene discussed is CLYBL; the disease is major depressive disorder.