The altered craniofacial phenotype (brachycephaly) in HMGA2-null rabbits (Carneiro et al. 2017) along with human GWAS indicating an association with craniofacial morphology, especially in the upper region of the face and nose (Fatemifar et al. 2013; Moreno Uribe et al. 2015), suggests that HMGA2 may have possible pleiotropic effects on craniofacial development. Here, HMGA2 is linked to Brachycephaly.