SERPINB4 and neoplasm: Based on previous studies, lymph node metastasis influences serum levels of SCCA1 in tumor size, even in early stages of cervical SCC.28 Our results confirmed findings of Yasumatsu, et al.21 (2001), suggesting that peripheral T-lymphocytes increase SCCA1 serum; however, we found that, besides T-lymphocytes, tumor cells can also express SCCA1.