IL6 and blood coagulation disease: In this study, early PAP values positively correlated with peak plasma IL-6 values (R2 = 0.445, P = 0.0018) and negatively correlated with the lowest platelet count in patients prior to surgical intervention (R2 = 0.425, P = 0.0014), thereby associating with both inflammation and coagulopathy markers, respectively (Figure 4A).