On a cytokine panel, we observed the greatest difference in plasma between muscle injury alone and burn with muscle injury in IL-6 measurements (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.154439DS1), and this difference in plasma has been shown to be an accurate predictor of SIRS and MODS (5, 31, 46). Here, IL6 is linked to systemic inflammatory response syndrome.