Furthermore, ISH staining confirmed the LINK-A expression was increased in synovial tissue from patients with established RA compared with that in HCs (Figure 1, I and J); moreover, as shown in Supplemental Figure 3, the LINK-A expression in synovial tissue was positively correlated with the severity of synovitis and disease activity score 28 (erythrocyte sedimentation rate) in patients with RA. Here, LINC01139 is linked to rheumatoid arthritis.