AD is characterized by three main changes occurring in the CNS: (1) Aβ plaque accumulation that prevents synaptic communication, (2) the accumulation of hyperphosphorylated tau proteins that inhibit the transport of molecules inside neurons, and (3) neuronal cell loss of the limbic system.5The basis of AD is explained by two main theories: (1) the “Aβ cascade hypothesis” emphasizing that it develops with the accumulation of oligomeric Aβ species in the CNS and (2) the “neurovascular hypothesis” that tries to determine the accumulation of Aβ species. This evidence concerns the gene MAPT and Alzheimer disease.