Enabling the movement of their substrates through intracellular organelles and cell membranes, ABC transporters, which provide the movement of its substrates from intracellular organelles and cell membranes, ensure the homeostasis of the body.6Recently, the emphasis on the role of ABC carriers in CNS disorders associated with high levels of Aβ, such as AD, has increased research into the causes of changes or dysfunction in the processes and pathways in which the carrier family is involved. Here, ABCB6 is linked to Alzheimer disease.