There is evidence that ABCA7, showing 54% homology with ABCA1, may be involved in AD pathology through Aβ accumulation and lipid metabolism.35Studies have reported thatABCA7genes are strongly linked to the immune response, cholesterol metabolism, and amyloid hypothesis affected in AD.36, 37Many investigators suggest that the relationship between ABCA7 and AD pathology is not direct but through lipid metabolism or immune response. The gene discussed is ABCA1; the disease is Alzheimer disease.