ABCG1 and Alzheimer disease: Coexpression of ABCG1 and APP has been shown to increase secreted levels of Aβ, indicating that ABCG1-mediated regulation of APP traffic supports the potential development of AD.57Other researchers have reported that ABCG1 significantly reduced Aβ production in cells expressing APP, suggesting that ABCG1 inhibits AD pathogenesis.