In the study conducted by Fu et al (2015), they determined that ABCA5 expression was significantly higher in the hippocampus of individuals with AD compared with the control groups.34In the same study, they determined that the decrease in Aβ level in cells transfected with ABCA5 was due to the change in APP processing (not APP expression).34 This evidence concerns the gene ABCA5 and Alzheimer disease.