Karayiorgou et al demonstrated differentially methylated sites inNR3C1,MTHFR,DRD4,5-HTT,IGF2DMR,H19, andKCNQ1OT1genes by using genome-wide DNA methylation in ASD patients.29Decreased level methylation ofPRRT1andTSPAN32was observed in the cerebellum and temporal cortex of brains from 19 autism cases and 21 controls.30, 31Stenz et al demonstrated hypomethylation ofITGB2 (C3R),SPI1,TNF-α,C1Q,IRF8m, andC3genes in brain tissue samples from 13 autism cases and 12 controls. The gene discussed is DRD4; the disease is autism.