The ability to capture a more representative cytokine microenvironment for psoriatic KCs, along with the integration of the cPLA2ɑ/PGE2/EP4 axis gave us access to an in silico experimentation system that allowed us to test a wide range of stimuli, observe the propagation of signals through the system, and predict the effects of mutations. This evidence concerns the gene PLA2G4A and dry eye syndrome.