We thus hypothesized that activation of the PGE2/EP4 axis is involved in an intrinsic amplification loop that could enable or sustain the effects of psoriatic cytokines and that suppression of the PGE2/EP4 axis by inhibition of cPLA2α presents a putative mode of action for AVX001 in psoriasis. This evidence concerns the gene PTGER4 and psoriasis.