RARA and colonic neoplasm: These observations are in line with recently published evidence for premature enterocyte differentiation in small intestinal organoids upon RAR-RXR activation (Lukonin et al., 2020), data that show decreased colon tumor initiation and metastasis upon RA treatment (Ordóñez-Morán et al., 2015), as well as with findings in other tissues concerning the differentiation-inducing capacity of RA signaling (Janesick et al., 2015; Mezquita and Mezquita, 2019; Theodosiou et al., 2010).