GSTM1 and cancer: Our criteria were based on then local unpublished data analysing acohort of 13,361 patients on 2WW colorectal cancer referral pathway.9 In those patients with a FIT>100 μg Hb/g, the CRC detection rate was 20.7%.9 The CRC detection rate inpatients with FIT 10–19.9 μg Hb/g was 1.4% and the overallCRC rate in patients with FIT <20 μg Hb/g was less than0.3% during the follow-up period, both of which are well below the recommended3% threshold for NICE urgent cancer referrals.9,10