We studied the relationship between OXTR levels and signaling pathways through KEGG enrichment analysis, finding that OXTR level was positively associated with four main well-studied signaling pathways in COAD, including the hedgehog, mTOR, TGF-β, and Wnt signaling pathways (Figure 6a). The gene discussed is TGFB1; the disease is colon adenocarcinoma.