PRKAA1 and Hypoglycemia: The ventromedial hypothalamic nucleus (VMN), a prominent neuroanatomical component of the MBH, is a likely source of AMPK gluco-regulatory signaling as hypoglycemia stimulates AMPK phosphorylation in VMN neurons that express neurotransmitters that inhibit (gamma-aminobutryic acid; GABA) or enhance (nitric oxide; NO) counter-regulatory hormone secretion [5],[6].