OSA: obstructive sleep apnea, COPD: chronic obstructive pulmonary disease, CRP-C: reactive protein, ESR: erythrocyte sedimentation rate, BNP: brain natriuretic peptide, CPK: creatinine phosphokinase, EF: ejection fraction, LGE: late gadolinium enhancement, NSAID: nonsteroidal anti-inflammatory drug, IVIG: intravenous immunoglobulin. This evidence concerns the gene PIK3C2A and chronic obstructive pulmonary disease.