NFKB1 and Insulin resistance: The Con-Can mice in this study showed higher body weight gain and insulin resistance (Figures 1 and 2), two important features of metabolic syndrome and risk factors for systemic and chronic inflammation; therefore, we examined the protein expression of NF-κB, STAT3, VCAM, NLRP3, and IL-1β in peritumor tissues (Figure 6).