TPI1 and breast carcinoma: A few years later, the Böhm group expanded differential tear protein analysis in breast carcinoma patients with MALDI-TOF-TOF semi-quantitative comparison proteomics, which found that some proteins were associated with various metabolic cascades such as triosephosphate isomerase (TPI) and aldehyde dehydrogenase 3A (ALDH3A), and host immune system pathways such as protein S100A8 (S100A8) and complement C1q subcomponent subunit C (C1Q1) [31].