Another studies found that anti-Ro/SSA and anti-La/SSB antibodies in tear fluid samples of Sjögren’s syndrome patients are associated with the severity of keratoconjunctivitis sicca [103], and that α-fodrin antibodies in tear fluid of Sjögren’s syndrome patients might be the activation markers of Sjögren’s syndrome (SS) [104]. This evidence concerns the gene CALR and Sjogren syndrome.