Zhang et al. detect the gene expression proportion of m6A-related proteins in 348 ESCC tissues by using ELISA and find that the expressions of METTL3 and METTL14 in ESCC pathological tissues are significantly upregulated, while the expressions of FTO and ALKBH5 are significantly downregulated, compared with normal tissues. This evidence concerns the gene ALKBH5 and esophageal squamous cell carcinoma.