Furthermore, to be more specific in another way on actions and mechanisms of TCM in mitigating hyperuricemia, this review will be divided into several parts based on the different actions of herbs, including inhibition of XOD effects (mainly in the liver or serum), regulation of urate transporters in the kidney or urate transporters in the intestine, antioxidant, and anti-inflammatory effects (Table 1). This evidence concerns the gene SLC2A9 and hyperuricemia.