VTCN1 and pachyonychia congenita: As shown in Figure 7, the expression of PD-1, CTLA4, CD86, VTCN1, and LAG-3 of PC patients of the CIMP-H subgroup was significantly lower than that of patients of the CIMP-L subgroup (Figures 7(a), 7(c), 7(e), 7(h)–7(j)).