STAT3 and pachyonychia congenita: Moreover, Cardoso et al. have showed that the DNA binding and transcriptional activity of STAT3 is regulated by APE1 and dual targeting of APE1 and STAT3 could synergistically inhibit the survival and migration of PC cells, which suggests that the synergistic effects may have been due to enhancement of STAT3 inhibition by inhibition of APE1 [38].