APOE and atherosclerosis: Macrophages overexpressing 12/15-lipoxygenase (12/15-LO) show increased levels of lipoxin A4, which downregulates several proinflammatory cytokines, resulting in atheroprotection in ApoE−/− mice overexpressing 12/15-LO in macrophages and increased atherosclerosis in ApoE−/− 12/15-LO−/− mice [251].