DAXX and neurodevelopmental disorder: Here, we report de novo missense and stop-loss variants in H3-3A (n = 6) and H3-3B (n = 6) in 12 individuals with neurodevelopmental disorders and multiple system abnormalities and a potentially perturbed interaction between one H3.3 mutant and the chaperone death domain-associated protein 6 (DAXX) using transiently transfected cell models.