Interestingly, none of the individuals reported so far has had any type of cancer, although the variants previously implicated in somatic cancer development were reported by Bryant et al., and we showed enhanced binding of H3.3 protein composed of mutated H3-3A isoform to DAXX which was also implicated in molecular mechanism of H3-3A-mediated cancer development20. The gene discussed is H3-3A; the disease is cancer.