Furthermore, the protein and mRNA levels of hypertrophic biomarkers (β-MHC and BNP) were lower in the co-transfected group than in the lncRNAA02Rik only group (Fig. 7B–E), indicating that lncRNAA02Rik promoted cardiac hypertrophy by sponged miR-135a. Here, NPPB is linked to cardiac hypertrophy.