MAPT and Alzheimer disease: Indeed, recent work has shown that chronic unpredictable stress and high GC levels induce AD-like pathology in animal models, including the overproduction of toxic amyloid-beta (Aβ) peptides, as well as the accumulation, hyperphosphorylation, and synaptic missorting of Tau protein, leading to synaptotoxicity and memory impairment [4–9].