KEAP1 and cancer: Furthermore, the transcriptional effects of OGT were also previously associated with inactivation of nuclear factor E2-related factors, like nuclear factor E2-related factor 2 (NRF2), in various expression datasets of cancers, wherein kelch-like ECH-associated protein 1 (KEAP1) inversely mediated the NRF2 protein, as a direct substrate of OGT [10].