ANGPT2 and lymphedema: Furthermore, genetic predisposition may play a role when secondary lymphoedema develops in other contexts, for example, after surgery for breast cancer.34 35 Cellulitis is a well-recognised complication of primary lymphoedema.36 Whether or not clinically unaffected heterozygotes for a pathogenic ANGPT2 variant are at increased risk of secondary lymphoedema and subsequently for cellulitis is not known.