HMGB1 and cancer: Damage-associated molecular patterns (DAMPs) such as S100A8/9, high mobility group box 1 (HMGB1), or uric acid are released from damaged cells under a variety of pathological conditions including cancer and have been implicated in leukocyte trafficking.19 Consequently, these DAMPs might mediate the recruitment of excessively aging neutrophils in cancer to malignant tumors.