Previously, CXCL2 has been reported to mediate phenotypic and functional changes related to chronological aging of neutrophils (‘biological aging’) under homeostatic conditions in an autocrine manner,13 in addition to its well-known chemotactic properties.23 We therefore hypothesized that these tumor-released molecular signals promote such age-related changes in circulating neutrophils. Here, CXCL2 is linked to neoplasm.