Importantly, direct exposure of NLRP3 activating alum crystals or of the NLRP3 inhibitor as well as of blocking antibodies directed against CXCR2 or of the CXCR4 inhibitor did not significantly change the proliferation of SCC VII or 4T1 tumor cells in vitro (figure 5D). The gene discussed is NLRP3; the disease is neoplasm.