Blockade of the CXCL2 receptor CXCR2, which interferes with neutrophil biological aging,13 reduced tumor growth and—in line with recent observations38 and most probably due to the downregulation of CXCR2 on excessively aging neutrophils—did not significantly affect neutrophil trafficking into malignant lesions or directly modulate tumor cell proliferation. Here, CXCR2 is linked to neoplasm.