Moreover, neutrophil depletion did not significantly alter numbers of CD4+ or CD8+ T cells in the malignant lesions (figure 6F) as well as the proliferation of these immune cells (determined by Ki-67 immunostaining; online supplemental figure S8), collectively suggesting that excessive aging of neutrophils in cancer particularly promotes NE-dependent tumor cell proliferation. The gene discussed is CD8A; the disease is cancer.