HMGB1 and cancer: DAMPs such S100A8/9, HMGB1, or uric acid, however, are constantly released on cell injury under pathological conditions, including oncological disorders.19 In our experiments, we found that SCC VII as well as 4T1 cancer cells abundantly produce uric acid and—to a much lesser degree—HMGB1, but not S100A8/A9.