PRTN3 and rheumatoid arthritis: A recent study by Rogier et al. [23] showed a great proportion of ACPA-positive CSA patients with subclinical synovitis in 3 different cohorts (54, 44 and 68%, respectively) did not develop IA, and concluded that using subclinical synovitis by US or MRI to identify RA introduces a high false-positive rate, suggesting an overestimation regarding the value of ACPA positivity in combination with the presence of subclinical synovitis in patients with CSA.