Correspondingly, DDR2 is a collagen-binding receptor tyrosine kinase, and the GVMGFO collagen motif is believed to be the primary site for specific DDR2 recognition and binding; this combination causes a DDR structural change and subsequent phosphorylation and activation, which are extensively involved in cell development, extracellular matrix turnover, growth regulation, and cancer-related functions [31, 32]. The gene discussed is DDR2; the disease is cancer.