In addition, HS-mimetic and laminin-mimetic peptide amphiphile nanofibers substantially enhance dopamine and tyrosine hydroxylase levels, reduce cleaved Cas-3 level, and improve function and tissue integrity in the 6-hydroxydopamine-induced PD model in rats [326], indicating a therapeutic potential of laminin and HS in PD. This evidence concerns the gene LAMB2 and Parkinson disease.