In addition, HS-mimetic and laminin-mimetic peptide amphiphile nanofibers substantially enhance dopamine and tyrosine hydroxylase levels, reduce cleaved Cas-3 level, and improve function and tissue integrity in the 6-hydroxydopamine-induced PD model in rats [326], indicating a therapeutic potential of laminin and HS in PD. The gene discussed is EFS; the disease is Parkinson disease.