Univariable Cox hazards analyses showed that subjects with male sex, Raynaud’s phenomenon onset after the age of 45, disease onset after the age of 50, cardiac involvement, PAPs > 35 mm Hg, DLCO <70%, FVC <65%, SRC, anemia, CRP > 5 mg/l, and albumin < 35 g/l had a higher risk of death (see Appendix). This evidence concerns the gene CRP and anemia.