The high expressions of caveolae-associated protein 2 (CAVIN2 or SDPR) and glutathione peroxidase 1 (GPX1) genes in DS were mainly related to exocytosis, platelet decomposition and endocytosis (Fig. 2B and C), indicating that the TCM syndromes in CRC and may be related to the heterogeneity of genes and their function and signaling pathways in tumor cell subpopulations. The gene discussed is GPX1; the disease is colorectal carcinoma.