We found epithelium-specific ETS transcription factor 3 (ELF3), keratin 8, 18 and 19 (KRT8, 18 and 19), fibronectin 1 (FN1), serpin family Emember 1 (SERPINE1), transcription factor 4 (TCF4) and zinc finger E-box binding homeobox 1 (ZEB1) genes have significant differences in ES, DS and DES of CRC (P < 0.01) (Table 3). This evidence concerns the gene SERPINE1 and colorectal carcinoma.