Moreover, there were the different distributions of intra-tumor cell subpopulations in different TCM syndromes including ES, DS and DES, and the high expressions of MUC2 and REG4 in DES were mainly related to brain development, cytogenesis, MAPK and cAMP signaling pathways; the high expressions of COL1A2 and POSTN genes in ES were mainly related to vascular development, skeletal muscle development, and PI3k-Akt Pathway; SDPR and GPX1 genes were highly expressed in DS, mainly related to vomiting, platelet decomposition, and endocytosis. Here, REG4 is linked to neoplasm.