AKT1 and hereditary elliptocytosis: On the other hand, a significant group effect was observed in the expression of AKT (F(2, 13) = 4.43, p = 0.034), in which both 10 mg/kg (p = 0.037) and 25 mg/kg HE (p = 0.018) groups had reduced AKT protein levels compared with the CRS + saline group (Fig. 6D), whereas CRS increased AKT phosphorylation (p = 0.047).