Multiple comparisons revealed that TMZ could effectively abolish the influence of 10 mg/kg HE, but not 25 mg/kg HE, on hippocampal GFAP expression, as indicated by increased GFAP+ cell count in the CA1 and DG of 25 mg/kg HE group (Fig. 9E–H). This evidence concerns the gene GFAP and hereditary elliptocytosis.