Further analysis revealed reduced Bdnf (p = 0.002) and Psd-95 (p = 0.047) transcript expressions in the CRS + saline group compared with the non-CRS control group, and higher gene expressions of Bdnf, Syp, Nes, and Psd-95 in both the 10 mg/kg HE group (p = 0.001; p < 0.001; p < 0.001; p = 0.002, respectively) and 25 mg/kg HE group (p = 0.047; p = 0.007; p = 0.012; p = 0.024, respectively) compared with the CRS + saline group. The gene discussed is BDNF; the disease is hereditary elliptocytosis.