Transcriptional profiling of nasopharyngeal swabs showed inflammatory response genes, IFN-α response, IL6/JAK/STAT3 signalling, and complement cascade activation in COVID-19 patients, while a down-modulation of anti-inflammatory pathways was observed by scRNAseq in CD14+ /CD16+ cells from severe patients [TE99]. The gene discussed is IFNA1; the disease is COVID-19.