Specifically, IFN, TNF and NF-kB pathways, cytokine SPP1, GRN, the receptor tyrosine kinase AXL [TE85], NLR and RIG-I signaling are strongly altered by SARS-CoV-2 [TE76], contributing to severe forms of COVID-19 [6]. The gene discussed is IFNA1; the disease is COVID-19.