Genomics studies suggest that ACE2 polymorphisms might be associated with cardiovascular and pulmonary conditions by altering the AGT-ACE2 interactions, and transcriptomics data confirm the upregulation of the gene encoding ACE2 receptor in lung tissue in several comorbidities associated with severe COVID-19, such as COPD or PAH, and even in people who smoke. The gene discussed is ACE2; the disease is pulmonary arterial hypertension.