Utilizing the hydrophilicity and editability of DNA nanostructures, Tian et al. [43] modified TDN with angiopep-2 (ANG-TDN), which showed a strong binding to the low-density lipoprotein receptor-related protein-1 (LRP-1) of glioma and the blood–brain barrier (BBB) cells. Here, LRP1 is linked to central nervous system cancer.