SOX1 and cholangiocarcinoma: As expected, miR-155-5p promoted the proliferation of CCA cells; however, overexpression of SOX1 blocked the stimulatory effect of miR-155-5p on the proliferation of CCA cells, indicating that downregulation of SOX1 is an important mechanism by which miR-155-5p promotes cell proliferation (Fig. 5A, C).