The SOX family is closely related to tumorigenesis and development; for example: SOX2 interacts with BCL11A to control the development of lung squamous cell carcinoma [9]; hypoxia may increase the hepatocellular carcinoma (HCC) stem cell population via altering the AR/miR-520f-3p/SOX9 signaling [10]; SOX17 is involved in the p53-mediated apoptosis pathway, and increases the sensitivity of endometrial cancer cells to cisplatin [11]. The gene discussed is SOX2; the disease is hepatocellular carcinoma.