Wadhwa et al. used the molecular docking software Autodock to predict that caffeic acid phenylethyl ester (CAPE) could dock with mortalin and prevent the formation of mortalin-p53 complex, resulting in nuclear ectopia of mortalin and activation of the p53 anti-cancer function, and inhibit the growth of cancer cells through the p53-GAD45a-p21 pathway [22]. The gene discussed is TP53; the disease is cancer.