Considering the important link between the EMT/RECK–STAT3 signaling pathway/MMPs and tumor cell migration/invasion, HCCLM3 cells were treated with Sal B at 0.0, 50.0, 100.0, and 200.0 μM for 48 h, and the expressions of EMT-related proteins, including E-cadherin, N-cadherin, and vimentin, were analyzed. This evidence concerns the gene STAT3 and neoplasm.