Subgroup-specific genes with strong effects on overall survival and high MIFs in the proposed weighted model involve the following cancer-related genes: ADH1C, BMP5, LCN2 and PLOD2 in GSE31210, CST1 in GSE37745, as well as AREG and COL4A3 in GSE29013. The gene discussed is COL4A3; the disease is cancer.