Among them, 15 genes (IL1A, GSDMA, TP53, NLRP6, GSDMC, IL1B, NLRC4, IL18, CASP5, CASP3, IRF2, BAK1, PYCARD, CHMP2B, and NOD2) were upregulated, while 19 other genes (CASP6, CHMP7, ELANE, BAX, CHMP2A, CASP9, GPX4, CYCS, CASP8, PRKACA, TP63, IRF1, PLCG1, CHMP3, GSDMD, CHMP4C, NOD1, CASP4, and IL6) were downregulated in the glioma group. The gene discussed is CASP3; the disease is glioma.