Among them, 15 genes (IL1A, GSDMA, TP53, NLRP6, GSDMC, IL1B, NLRC4, IL18, CASP5, CASP3, IRF2, BAK1, PYCARD, CHMP2B, and NOD2) were upregulated, while 19 other genes (CASP6, CHMP7, ELANE, BAX, CHMP2A, CASP9, GPX4, CYCS, CASP8, PRKACA, TP63, IRF1, PLCG1, CHMP3, GSDMD, CHMP4C, NOD1, CASP4, and IL6) were downregulated in the glioma group. The gene discussed is CASP6; the disease is central nervous system cancer.