Among them, 15 genes (IL1A, GSDMA, TP53, NLRP6, GSDMC, IL1B, NLRC4, IL18, CASP5, CASP3, IRF2, BAK1, PYCARD, CHMP2B, and NOD2) were upregulated, while 19 other genes (CASP6, CHMP7, ELANE, BAX, CHMP2A, CASP9, GPX4, CYCS, CASP8, PRKACA, TP63, IRF1, PLCG1, CHMP3, GSDMD, CHMP4C, NOD1, CASP4, and IL6) were downregulated in the glioma group. Here, IRF1 is linked to central nervous system cancer.