Similarly, several inflammatory mediators, identified earlier by QPCR in trigone biopsies of BPS patients using TaqMan microfluidic cards [10], showed similar regulation of expression: CCL21 (log2 FC 1.15, p value 0.01) and CXCL1 (log2 FC 0.76) mRNAs were both significantly up-regulated in our NGS dataset. The gene discussed is CXCL1; the disease is Bartsocas-Papas syndrome 1.