The most differentially expressed gene in C1 was DSP (P = 4.15 × 10−72, fold change 2.20), which was followed by MUC16 (P = 2.64 × 10−64, fold change 3.65), a strong predictor for disease progression and mortality in IPF [50]. This evidence concerns the gene MUC16 and idiopathic pulmonary fibrosis.