CD68 and metastatic malignant neoplasm in the lymph nodes: The analysis of CD68+ and CD163+ macrophage infiltration densities and clinicopathological parameters showed that the number of patients with a high infiltration density of the M2 macrophage marker CD163+ in the TS was significantly higher than that of patients with a low infiltration density in TNM stage III + IV (P < 0.05), but there was no significant difference in age, tumor diameter, lymph node metastasis or grade, as shown in Table 2.