We first analyzed the expression of eIF4E in a variety of tumors and normal tissues using the Oncomine database and found that the expression of eIF4E in brain cancer, BRCA, cervical cancer, colorectal cancer, gastric cancer, head and neck tumor, kidney cancer, lung cancer, lymphoma, ovarian cancer, pancreatic cancer, sarcoma and other tumors was higher than that in normal tissues (P < 0.001) (Fig. 1A). This evidence concerns the gene EIF4E and lung carcinoma.