According to the analysis of sample type, age, subtype of BRCA, disease stage, lymph node metastasis and TP53 mutation, the expression of eIF4E in BRCA patients was significantly higher than that in normal controls, and the expression of eIF4E in patients aged 61 to 80 was significantly higher than that in patients aged 41 to 60 (P = 0.037399). This evidence concerns the gene TP53 and metastatic malignant neoplasm in the lymph nodes.