NFKB1 and esophageal squamous cell carcinoma: Ivermectin markedly increased ROS levels of ESCC cells and scavenging the ROS by NAC surprisingly blocked the apoptosis and NF-κB inactivation, suggesting that ROS-mediated apoptosis was the main mechanism for ivermectin activity, while other pathways may also play a role to be explored in the future.