In the ten studies tha t examined patients with BE, the prevalence of the CagA-positive H p strain was significantly lower than that in controls (208/1080 [20.5%] vs 605/2070 [29.1%]) (OR = 0.28; 95% CI, 0.15–0.54, P = 0.0002; I2 = 83%) (Fig. 6) [12, 38, 45, 47, 54, 58, 59, 69, 71, 72]. The gene discussed is S100A8; the disease is Barrett esophagus.