IL18 and acute coronary syndrome: Although prescription of 1/mg daily colchicine for 30 days would not decrease inflammation and hs-CRP in patients with acute coronary syndrome or acute ischemic stroke in Raju et al. [24] study, in yet another survey, Martinez et al. demonstrated a significant reduction of level of inflammatory cytokines such as IL-1β, IL-18 and IL-6 after a short-term administration of colchicine in ACS patients [16].