AKT1 and depressive symptom measurement: The key targets of JTW in treating DM and depression probably were INS, AKT1, IL-6, VEGF-A and TNF, and the underlying mechanism would be associated with modulation on HIF-1 signal pathway, pathways in cancer, Hepatitis B, TNF signal pathway, PI3K-Akt signal pathway and MAPK signaling pathway and so on.