PLIN4 and type 2 diabetes mellitus: In keeping with these findings, PLIN4 LoF was nominally associated with an increased risk for type 2 diabetes (T2D) (odds ratio [OR] = 1.36 [1.06-1.66], P = .04) in the Type 2 Diabetes Knowledge Portal (T2DKP; https://t2d.hugeamp.org/), though none of the genes showed a significant association with T2D in the UK Biobank through our analysis or in the AstraZeneca PheWAS Portal (https://azphewas.com/) (Supplementary Fig. 2, Supplementary Table 9, and Supplementary Table 10) (14).