TP53 and neoplasm: Whole-exome sequencing (n = 168 tumours) identified 16,134 somatic mutations (Supplementary Table 2), with the highest frequency in driver genes, including TP53 (n = 96, 57%), PIK3CA (n = 44, 26%), GATA3 (n = 16, 10%) and MAP3K1 (n = 13, 8%) (Extended Data Figs. 3, 4a).