Conversely, a case-control study of Australian infants born between 1997 and 1999, the period of changeover to aP-based schedules, reported a lower likelihood of IgE-mediated food allergy in infants primed with a first dose of wP, compared to those that received a first dose of aP [odds ratio: 0.77; 95% confidence interval (CI), 0.62 to 0.95] [19]. Here, IGHE is linked to food allergy.